What ended the Renaissance?

What ended the Renaissance?
In a broad sense the Renaissance didn't end, it spread acrosswestern Europe and fed into a succession of artistic andintellectual phenomena. But central & northern Italy's loss ofcultural leadership after the 15th century doubtless owes much tothe upheavals and economic downturn following the French invasionof 1494 and the subsequent 65 years of intermittent Valois-Habsburgwar, as well as to the shift of economic, cultural & politicalprimacy to north-western Europe following the discovery of theAmericas, the Reformation and the rise of national states.